The ISSA replacement brush heads are made from medical-grade silicone that resists bacteria buildup, making them ultra-hygienic. The quick-drying bristles of this replacement brush head are soft on the gums, easily removing stains for a healthier, brighter smile. It is designed to be used with the revolutionary ISSA Toothbrush. Available in all four vibrant hues: Mint, Lavender, Cobalt Blue, and Cool Black. Replace the brush head once per year.